Name of Supervisor Qun-Ying Lei Gender Female Date of Birth Mar.1971 Professional Title Full Professor Area of Expertise Cancer metabolism Whether Part-time No Research Direction Cancer metabolism, Hippo-TAZ pathway and post-translation modification in cancer development Current Research Projects NSFC 31071192 (Lei, PI) NSFC Title: TAZ expression and regulation in human breast cancer The objectives of this project are to study the TAZ degradation control mechanism and functional role in human breast cancer development. NSFC 31271454(Lei, PI) NSFC Title: Acetylation control of ATP –citrate lyase in lung cancer development The major goal of this proposal is to study the biochemical mechanism of ACL acetylation regulation and the contribution of ACL acetylation to tumorigenesis. NSFC 81225016(Lei, PI) NSFC Title: PKM2 acetylation regulation and function in tumor development The major goal of this proposal is to study the biochemical mechanism of PKM2 acetylation regulation in nuclear translocalization and nuclear PKM2 function in tumorigenesis. 973 2009CB918401 (Lei, PI) Chinese Ministry of Science and Technology Title: The function and mechanism of protein posttranslation modification in human disease. The main object of this project is to investigate the biochemical mechanisms of protein posttranslation modification to characterize their physical and pathological effect in human disease, particularly how acetylation regulating cancer metabolism. NSFC-NIH 81110313(Lei, PI) NSFC Title: Regulation and Function the The objectives of this project are to study the function of tight junction in YAP/TAZ regulation and contact inhibition. Name of Supervisor Guangwei Liu Gender Man Date of Birth Apr.1972 Professional Title Professor Area of Expertise Immunology Whether Part-time No Research Direction Immunological biological effects and mechanisms Current Research Projects National Nature Research Foundation(C31171407 and C81273201) Name of Supervisor Youhua Xie Gender Male Date of Birth Feb.1969 Professional Title Professor Area of Expertise Virology Whether Part-time No Research Direction Infection and pathogenesis of hepatitis B virus; Biomarkers of liver cancer Current Research Projects Prevention of hepatitis B virus infection by blocking viral entry; Novel biomarkers for hepatocellular carcinoma Name of Supervisor Danian Zhu Gender male Date of Birth Oct.1949 Professional Title Professor Area of Expertise Physiology Whether Part-time No Research Direction Central regulation on cardiovascular activities Current Research Projects 1. Central mechanisms of Orexin on the incidence of hypertension and cardiac ischemia and of the therapeutic effect of acupuncture on these cardiovascular diseases. 2009-2012, the foundation is from Ministry of Education for doctorial training, RMB 60 thousands in total. 2. Central mechanisms of sensitization of OT- and AVP-ergic neurons in the PVN mediated by P2X7 signaling of microglia participating in the central control of cardiac infarction. 2013-2016, the foundation is from national natural scientific foundation committee, RMB 850 thousands in total. Name of Supervisor Yi-chun ZHU Gender Male Date of Birth Sep.1963 Professional Title Professor Area of Expertise physiology Whether Part-time No Research Direction Identification of the “receptor” for hydrogen sulphide in the cardiovascular system The mechanisms underlying cardiac myocytes apoptosis; The role of hydrogen sulfide in regulating cardiac ion channels ; New approaches to regulate angiogenesis in ischemic hearts; Effects of ingredients from natural products in the cardiovascular system. Current Research Projects National Science Fund for Distinguished Young Scholars (30825016) National Natural Science Foundation of National Basic Research Program of Doctoral Fund of Ministry of Education of The Science and Technology Commission of National Science and Technology Major Project (2012ZX09501001) Name of Supervisor Qiliang Cai Gender Male Date of Birth Oct.1976 Professional Title Professor Area of Expertise Molecular Tumor Virology Whether Part-time No Research Direction Microenvironmental stress and Tumor Virology Current Research Projects 1. The role of microenvironmental hypoxia on gamma-herpesvirus induced oncogenesis. 2. The research and development of hypoxia-responsive small molecules on therapeutic application of virus-mediated cancer. Name of Supervisor Yiwei chu Gender female Date of Birth Nov.1964 Professional Title Professor Area of Expertise Immunology Whether Part-time No Research Direction Tumor Immunology Immunoregulation in autoimmune disease Current Research Projects Prof. Chu focuses her researches on tumor immunity and immunotherapy as well as the role of immunoregulation in autoimmune disease (AID). In recent years, she has presided or taken part in many research projects funded by National 973 Project, National Key Technologies R & D Program of China during the Eleventh Five-Year Plan Period, National Natural Science Foundation, the Science and Technology Commission of Shanghai Municipality and the “Dawn” Program of Name of Supervisor Jianxin Gu Gender male Date of Birth May. 1958 Professional Title professor Area of Expertise Biochemistry and molecular biology Whether Part-time No Research Direction Tumor & glycobiology (tumor development, tumor immunity, drug resistance of tumor ) Current Research Projects frontier research in Carbohydrate Chemistry and glycobiology on tumor; the functions and mechanisms of important proteins regulating cell growth; basic and applied research on glycoprotein and structure of carbohydrate chains; research on hepatitis and viral hepatitis. Name of Supervisor Ma Duan Gender Male Date of Birth May. 1963 Professional Title Professor Area of Expertise Medical Genetics and Molecular Genetics Whether Part-time No Research Direction Mechanisms, prevention and treatment of Birth Defects and cardiovascular diseases Current Research Projects 1. The national key basic research program of 2. The national basic research program of 3. The National Natural Science Foundation of 4. Shanghai outstanding academic leaders program: Novel function of TFPI-1 5. Shanghai Key basic research program: Prevention and treatment of ten rare diseases Name of Supervisor Xing Zhong Wu Gender Male Date of Birth Jul.1957 Professional Title PhD Area of Expertise Tumor metastasis Whether Part-time No Research Direction 1. Fucosylation of cell glycoprotein is one of our research areas, in which we investigated the fucosylation in lung cancer cells and hepatocellular carcinoma cells and observed that fucosylation of E-cadherin and chemokine receptors is important in the regulation of tumor cell migration and is associated with their metastasis potential. 2. Sulfation of glycan is another area of our research, in which we are investigating the role of the sulfated mioties of cerebroside in tumor metastasis. In this area our interests focus on the regulation of integrin alpha V subunit gene expression. Based on our previous observation that demonstrated the regulation, we will look further into the signaling or regulatory pathway to elucidate the possible mechanisms. . Current Research Projects Cerebroside sulfation in regulation of integrin alpha V subunit gene expression. Signaling pathway mediated by core-fucosylated E-cadherin Name of Supervisor Bing-Qiao Zhao Gender Male Date of Birth Oct.1966 Professional Title Professor, State Key Laboratory of Medical Neurobiology, Area of Expertise Stroke, Cerebral hemorrhage, Neurogenesis Whether Part-time No Research Direction The relationships of neurovascular components to neurons after brain injury and self-repair Current Research Projects 1. The cellular and molecular responses to thrombolytic-induced hemorrhage in stroke therapy; 2. The mechanisms that mediate and modulate angiogenesis and neurogenesis after brain injury Name of Supervisor Zhongren Ding Gender Male Date of Birth Sep.1968 Professional Title Research professor Area of Expertise Biochemistry and Molecular Biology Whether Part-time No Research Direction Mechanism of platelet activation and antiplatelet drug Current Research Projects Current Research Projects: R & D of novel antiplatelet agents Name of Supervisor Feng-Yan SUN Gender Female Date of Birth 1953 Professional Title Professor Area of Expertise Neurobiology Whether Part-time No Research Direction Neuroprotection and neural repair in the brains after ischemic injury Current Research Projects Cellular and molecular mechanisms of neural repair in brain after ischemic stroke-A key project supported by National Natural Science Foundation of China. Name of Supervisor Songwen Zhang Gender Male Date of Birth 1977 Professional Title Professor Area of Expertise Biochemistry and molecular biology Whether Part-time No Research Direction Identification and validation of molecular target for human diseases. Current Research Projects Non-alcoholic liver disease, alcoholic liver disease and related liver diseases. Name of Supervisor Yuzhen Tan Gender Female Date of Birth Jul.1953 Professional Title Professor Area of Expertise Histology and Embryology Whether Part-time No Research Direction Differentiation of adult stem cells and cardiovascular regeneration, molecular biology of cardiovascular system. Current Research Projects Transplantation of cardiac stem cells carried with the self-assembling peptide for repairing infracted myocardiun. Activating epicardium with transplantation of nanomaterial-stem cell patch for treatment of myocardial infraction.