Name of Supervisor

Pengyuan Yang

Gender

Male

Date of Birth

Jun.1949

Professional Title

Professor

Area of Expertise

Mass Spectrometry, Proteomics

Whether Part-time

No

Research Direction

Disease related proteomics; technology of Mass Spectrometry

Current Research Projects

Quantitative Proteomics; Protein Glycosylation, HCC Related System Biology, Metabolomics, Instrumentation of Mass Spectrometry

Name of Supervisor

Xiangshi TAN

Gender

Male

Date of Birth

Sep.1964

Professional Title

Professor

Area of Expertise

Chemical Biology

Whether Part-time

No

Research Direction

Bioinorganic Chemistry; Chemical Biology; Biochemistry/Biophysics

Current Research Projects

1.  Structure, Function and Mechanism of Metalloproteins and Metalloenzymes

2.  Structural Base and Molecular Mechanism of NO Signal Transduction Mediated via Human Soluble Guanylate Cyclase

3.  Metal Homeostasis and Regulation in  Alzheimer’s disease (AD)

Name of Supervisor

Qun-Ying Lei

Gender

Female

Date of Birth

Mar.1971

Professional Title

Full Professor

Area of Expertise

Cancer metabolism

Whether Part-time

No

Research Direction

Cancer metabolism, Hippo-TAZ pathway and post-translation modification in cancer development

Current Research Projects

NSFC 31071192 (Lei, PI)                           01/01/11 - 12/31/13

NSFC

Title: TAZ expression and regulation in human breast cancer

The objectives of this project are to study the TAZ degradation control mechanism and functional role in human breast cancer development.

NSFC 31271454(Lei, PI)                       01/01/13 - 12/31/16

NSFC

Title: Acetylation control of ATP –citrate lyase in lung cancer development

The major goal of this proposal is to study the biochemical mechanism of ACL acetylation regulation and the contribution of ACL acetylation to tumorigenesis.

NSFC 81225016(Lei, PI)                            01/01/13 - 12/31/16

NSFC                                                      

Title: PKM2 acetylation regulation and function in tumor development

The major goal of this proposal is to study the biochemical mechanism of PKM2 acetylation regulation in nuclear translocalization and nuclear PKM2 function in tumorigenesis.

973  2009CB918401 (Lei, PI)               01/01/09 -08/31/13

Chinese Ministry of Science and Technology           

Title: The function and mechanism of protein posttranslation modification in human disease.

The main object of this project is to investigate the biochemical mechanisms of protein posttranslation modification to characterize their physical and pathological effect in human disease,   particularly how acetylation regulating cancer metabolism.

NSFC-NIH 81110313(Lei, PI)              01/01/12-12/31/12

NSFC

Title:  Regulation and Function the YAP Transcription Co-activator Oncoprotein

The objectives of this project are to study the function of tight junction in YAP/TAZ regulation and contact inhibition.